D1-like Dopamine Receptors Potentiate N-methyl-D-aspartate Induced the Gain Modulation in the Premotor Nucleus of Adult Zebra FinchesName : Dr. Dongfeng Li
Affliation : Professor
University : South China Normal University
Country : China
Interaction between dopamine (DA) and N-methyl- D-aspartate (NMDA) in the brain play an important role in learning and memory. In the songbirds, the premotor robust nucleus of the arcopallium (RA) receives excitatory glutamatergic inputs from the high vocal center (HVC) and lateral magnocellular nucleus of the anterior nidopallium (LMAN), RA as well as receiving dopaminergic inputs mostly from the periaqueductal gray (PAG) and ventral tegmental area (VTA). In zebra finch, DA potentiates the excitability of projection neurons in the RA through activation of D1-like dopamine receptors (D1 receptors). The relationship between D1 receptors and NMDA in the RA projection neurons is essentially unknown. Our previous work showed that NMDA can induce gain modulation in the RA projection neurons. Here, using the whole-cell current-clamp recording from brain slices of male zebra finches, we observed whether D1 receptors regulate of NMDA induced gain modulation in RA projection neurons. Our results demonstrated that activation of D1 receptors further increased the slope (gain) of the firing frequency-injected current (f-I) relationship induced by NMDA in the RA projection neurons. Blocking D1 receptors have no effect on the NMDA induced gain modulation in RA projection neurons. The enhanced effects of D1 receptors agonists were blocked by protein kinase A (PKA) inhibitors. Our results suggested that D1 receptors can increase the gain modulation induced by NMDA through a PKA-dependent pathway.
This work was supported by the National Natural Science Foundation of China?31472002?.
Professor Dongfeng LI graduated in 1982 from Northeast Normal University. Now he is Professor of School of Life Sciences, Institute of Neurophysiology, South China Normal University, member of Comparative Physiology Committee of CAPS, director of Guangdong Biophysical Society, member of the International Brain Research Organization, and member of AAAS. He worked the Auckland University in New Zealand, a Research Scholar of Key Laboratory of visual information processing of Chinese Academy of Sciences.