Severe brain injuries frequently result in disorders of consciousness, requiring intensive care unit treatment. There is a rehabilitative system that integrates neurorehabilitation into intensive care treatment. This system will be described using the case report of a patient in a vegetative state after a severe traumatic brain injury that resulted in major medical problems and complications. Despite these challenges, interdisciplinary therapies can be applied throughout the rehabilitative process. Patients show significant improvements and functional gains during the course of treatment.