The aged brain can learn and relearn due to the phenomenon is known as Neuroplasticity. Neuroplasticity is done by developing of new synaptic connections and creating new pathways in the brain. Neurorehabilitation plays an important role in neural plasticity and functional recovery following neurological disease. Neurorehabilitation is based on rehabilitation medicine, neuroscience, and neurophysiology. Neurorehabilitation could effectively induce neural plasticity and support for functional recovery. Neurophysiology and neuroimaging are great tools for revealing neural plasticity induced by neurorehabilitation. The field of neurorehabilitation is now beginning to capitalize on this body of work to develop neurobiologically informed therapies focused on key behavioral and neural signals driving neural plasticity. Neural plasticity is the neurobiological mechanism supporting functional improvement after brain injury.